GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7714584 | 1 | rs10053750 | chr5:150270051 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.24 | 1.17E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10057988 | chr5:150272062 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 5.97 | 5.47E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10058821 | chr5:150226385 | LOC134466 | chr5:150310000-150326146:- | 0.4 | 4.98 | 9.62E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10058943 | chr5:150226586 | LOC134466 | chr5:150310000-150326146:- | 0.4 | 4.98 | 9.62E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10061105 | chr5:150255185 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.27 | 9.54E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10065172 | chr5:150227998 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.35 | 1.52E-7 | Crohn's disease |
| BLCA | cis | rs2888674 | 1 | rs1006581 | chr7:150511923 | TMEM176A | chr7:150497854-150502208:+ | -0.17 | -4.54 | 7.38E-6 | Forced expiratory volume in 1 second (environmental interaction) |
| BLCA | cis | rs9885413 | 1 | rs10069077 | chr5:110170026 | TMEM232 | chr5:109624934-110062381:- | -0.36 | -4.03 | 6.69E-5 | Mortality in heart failure |
| BLCA | cis | rs10078 | 1 | rs10078 | chr5:438102 | C5orf55 | chr5:441645-443258:- | 0.3 | 4.35 | 1.71E-5 | Fat distribution (HIV) |
| BLCA | cis | rs7714584 | 1 | rs10078968 | chr5:150244273 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.77 | 1.66E-8 | Crohn's disease |
| BLCA | cis | rs10097215 | 1 | rs10097215 | chr8:2506899 | CLN8 | chr8:1711870-1734735:+ | 0.33 | 3.93 | 0.000101 | Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) |
| BLCA | cis | rs13256369 | 1 | rs10103769 | chr8:8573036 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -3.99 | 7.89E-5 | Obesity-related traits |
| BLCA | cis | rs13256369 | 1 | rs10110591 | chr8:8576608 | CLDN23 | chr8:8559666-8561616:+ | 0.27 | 5.01 | 8.27E-7 | Obesity-related traits |
| BLCA | cis | rs881375 | 1 | rs10117059 | chr9:123653477 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -6.08 | 2.96E-9 | Rheumatoid arthritis |
| BLCA | cis | rs7868228 | 1 | rs10119803 | chr9:21666066 | KLHL9 | chr9:21324054-21335429:- | -0.31 | -4.81 | 2.13E-6 | Gut microbiome composition (winter) |